Description
Orexin A (17-33) acts as selective OX1 antagonist. Truncation studies have led to OXA (17-33) as the shortest active peptide known to date with a 23-fold selectivity for OX1 over OX2. The native orexins A and B do not show distinct receptor selectivity. Both OX receptors are involved in energy homeostasis and the sleep/wake cycle, hence selective as well as dual antagonists are required for research.



